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Title: Effect of selective 5-HT6 serotonin receptor ligands on the activity of antipsychotic drugs in rats

Author:

Rychtyk, Joanna

Date:

2021

Type:

Praca doktorska

Abstract:

The aim of this study was to assess the effects of combined administration of a selective 5-HT6 receptor agonist (WAY-181187) or antagonist (SB-742457) with selected antipsychotic drugs (APD), i.e. haloperidol, risperidone, and olanzapine in in vivo and ex vivo studies in rats. Behavioral studies assessed effects of the tested compounds and their combinations on different cognitive functions disturbed by MK-801. In addition, their potential antidepressant and anxiolytic activities were assessed. Ex vivo studies included the assessment of the effect of the tested compounds and their combinations on the level of the brain-derived neurotrophic factor (BDNF) protein and its gene expression in the hippocampus and prefrontal cortex. 5-HT6 receptor ligands modified the activity of APD against memory deficits in various ways, depending on the test used. In addition, WAY-181187 reduced pro-depressive and anxiogenic effects of haloperidol. Both ligands, administered with risperidone, revealed an anxiolytic effect. The addition of 5-HT6 receptor ligands to olanzapine had no significant effect on the depressive and anxiety behavior of animals. The BDNF signaling pathway is not the only mechanism associated with the demonstrated pro-cognitive, antidepressant and/or anxiolytic activity of the tested substances and their combinations.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Rada Dyscypliny Nauki farmaceutyczne

Promoter:

Wesołowska, Anna ; Partyka, Anna

Date issued:

2021

Identifier:

oai:dl.cm-uj.krakow.pl:4599

Call number:

ZB-134220

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

5-HT6 receptor memory depression anxiety neuroleptics

Object collections:

Last modified:

Apr 8, 2024

In our library since:

Mar 31, 2022

Number of object content hits:

8

Number of object content views in PDF format

0

All available object's versions:

http://www.dl.cm-uj.krakow.pl:8080/publication/4600

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Edition name Date
ZB-134220 Apr 8, 2024

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