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Spałkowska, Magdalena
2020
Praca doktorska
In the first part of the study we assessed the expression of estrogen (α,β, GPER) and progesterone receptors in common nevi, dysplastic nevi, melanomas and healthy skin tissue margin. In the second part of the study we evaluated GPER expression in melanomas and margin tissue in men and women of different hormonal status. We have shown the presence of significant differences in estrogen β expressionin margin melanocytes between common and dysplastic nevi. Keratinocytes of melanomas and dysplastic nevi differed in estrogen receptor β expression. We did not show significant differences in estrogen α and β in relation to known prognostic factors in melanoma. Significant differences were found in estrogen β and GPER expression between margin and melanoma melanocytes. Melanocytes of melanomas and dysplastic nevi differed in GPER expression. There was a positive correlation between nuclear and cytoplasmic GPER expression in melanoma melanocytes and Clark and Breslow scales. There were differences in GPER expression in melanocytes concerning the presence of ulceration, mitotic figures and growth phase.
Kraków
2 - studia doktoranckie
dermatologia
Rada Dyscypliny Nauki medyczne
Wojas-Pelc, Anna
2019
oai:dl.cm-uj.krakow.pl:4425
ZB-132292
pol
nieograniczony
19 gru 2024
23 kwi 2021
215
14
http://www.dl.cm-uj.krakow.pl:8080/publication/4426
RDF
OAI-PMH
Dębicka-Kumela, Magdalena
Merklinger-Gruchała, Anna
Machowska, Agata
Krzych-Miłkowska, Karolina Maria
Ziomkiewicz-Wichary, Anna
Galbarczyk, Andrzej
Starmach, Anna
Styl cytowania: chicago-author-date iso690-author-date chicago-author-date
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