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The evaluation of tumor microenvironment in distinct breast cancer molecular subtypes

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Tytuł: The evaluation of tumor microenvironment in distinct breast cancer molecular subtypes

Autor:

Glajcar, Anna

Data:

2019

Typ:

Praca doktorska

Abstrakt:

The study aimed to investigate the infiltrate of immune cells (mast cells, T and B lymphocytes, cytotoxic, regulatory and T helper type 2 cells) in primary invasive breast cancer tissue excisions. Densities of respective immune cells were evaluated as the numbers of positively immunostained cells using light microscope and referred to breast cancer molecular subtype and other prognostic indicators. We found differences in densities of the immune cells that point to relationship between mast cells and clinically less aggressive breast cancer molecular subtypes as well as more favourable prognostic factors. More dense infiltrate of lymphoid, cytotoxic and regulatory cells was observed in clinically more aggressive subtypes of cancer and in tumors characterized by adverse prognostic indicators. The obtained results suggest a distinct role of immune cells in cancer progression, depending on breast cancer molecular subtypes and location of the cells in tumor tissue.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

onkologia ; ginekologia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Okoń, Krzysztof ; Szpor, Joanna

Data wydania:

2019

Identyfikator:

oai:dl.cm-uj.krakow.pl:4345

Sygnatura:

ZB-131177

Język:

pol; eng

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

breast cancer mast cells microenvironment lymphocytes

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

18 gru 2024

Data dodania obiektu:

25 cze 2020

Liczba wyświetleń treści obiektu:

187

Liczba wyświetleń treści obiektu w formacie PDF

8

Wszystkie dostępne wersje tego obiektu:

http://www.dl.cm-uj.krakow.pl:8080/publication/4346

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-131177 18 gru 2024

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Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

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