Title:

Noninvasive methods for endothelial function assesment in patients with risk factors for atherosclerosis

Author:

Wilk, Grzegorz

Subject:

flow mediated dilatation ; endothelial function ; arterial stiffness ; atherosclerosis ; risk calculators

Abstract:

Development of atherosclerotic changes in arteries is a multistage process.Endothelial dysfunction is an early stage of atherosclerosis.The aim of this study was to analyze relation of atherosclerosis risk factors,measured individually and by widely used risk scales with chosen methods of vascular function assessment.Relationships between markers investigated during measurements of arteries are also discussed.The study was conducted in 170 patients who had neither a history of CVD.Analysis of cardiovascular risk was performed using FRAMINGHAM2008,SCORE, PROCAM,QRISK2,ASCVD calculators.Assessment of endothelial function was performed using method of Flow Mediated Dilation of brachial artery and tonometry of peripheral arteries RHPAT.Arterial stiffness was analyzed using Pulse Wave Analysis,Pulse Wave Velocity.It was measured intima-media complex of the carotid artery.It was observed bFMD correlates with the largest number of singular risk factors for atherosclerosis and strongly correlates with the number of risk factors present in patients.The relationship between risk factors and other investigations of vascular functional was less clear.In all analyzed risk scales there was a correlation with bFMD,IMT,PWV.LnRHI correlated only with FRAMINGHAM2008 scale.A relationship between bFMD and IMT,LnRHI,APP, PWV was observed.IMT correlated with PWV,there was no correlation with LnRHI.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Guzik, Tomasz

Date:

2017

Date issued:

2016

Type:

Praca doktorska

Call number:

ZB-126594

Language:

pol

Access rights:

nieograniczony